Reduced Lecithin

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Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer.

PURPOSE Retinoids, which include vitamin A (retinol; ROL) and its derivatives, have been investigated in the treatment of bladder cancer. We have shown that expression of the enzyme lecithin:ROL acyltransferase (LRAT), which converts ROL to retinyl esters, is reduced in several human cancers. Here we evaluated expression of LRAT protein and mRNA in normal and malignant bladder tissue specimens ...

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Familial lecithin-cholesterol acyltransferase deficiency.

Familial lecithin-cholesterol acyltransferase deficiency is an uncommon autosomal recessive disorder from a heritable defect in esterification of plasma cholesterol. In 1968, the disease was described by Gjone and Norum in Norway. Our case was a 38-year-old woman. Her disease was manifested by presence of lower extremities edema, proteinuria, corneal opacities, increased plasma cholesterol, and...

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Lecithin Based Pseudoternary Phase Diagrams

Aim: Different promising colloidal delivery systems including microemulsions and liquid crystals could be obtained with suitable combination of oil, surfactants/cosurfactants and water. However, the main problem from a formulation point of view has been to choose the surfactants capable of forming such systems and be physiologically acceptable in the same time. To overcome the later shortcoming...

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Fatty Acids of Liver Lecithin

The phospholipids, along with cholesterol, are now recognized as essential elements of tissues, while the characteristic constituents of the phospholipids are the fatty acids. In any study of the metabolic activity of tissues the nature and proportions of the various fatty acids in the phospholipids therefore become important and have been the subject of increasing interest and speculation. Bec...

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A simplified purification of lecithin.

A practical and easily reproducible method for preparing lecithin of a high degree of purity is urgently needed in connection with the use of lecithin in cardiolipin antigens (1, 2). Methods devised for this purpose have been published (3, 4), but the procedures, based on the classic studies of Levene and his coworkers (5, 6), were somewhat tedious and the lecithins so prepared have not always ...

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ژورنال

عنوان ژورنال: Clinical Cancer Research

سال: 2004

ISSN: 1078-0432,1557-3265

DOI: 10.1158/1078-0432.ccr-03-0756